REV-ERB agonist comes up often in conversation and rarely with the context attached. Here we lay out the basics in order, then work through the practical considerations.
Last reviewed on 2026-05-10. Where a claim depends on a specific study, the study is described rather than over-claimed.
SR9009 is a synthetic small molecule studied as a REV-ERB agonist. REV-ERBα and REV-ERBβ are nuclear receptors that help regulate circadian rhythms and metabolic gene expression. The compound was identified in academic screening efforts to find synthetic ligands for these receptors. In cell and animal studies, SR9009 alters transcription of genes involved in lipid and glucose metabolism, and it can shift circadian behavior. It is not an approved therapeutic agent.
Mechanistically, SR9009 binds the ligand-binding domain of REV-ERBα/β and enhances recruitment of corepressor complexes. This represses target genes rather than activating them. Because REV-ERB proteins normally compete with ROR proteins at shared response elements, the net effect depends on tissue and timing. Researchers use SR9009 to probe how nuclear receptor signaling links the clock to metabolism, inflammation, and muscle biology. Findings are largely preclinical, and the precise contribution of each receptor subtype remains under study.
SR9009 is frequently discussed in fitness and research-chemical contexts, yet it has no approved medical indication. Regulatory agencies have not authorized it for human use, and it is not a standard prescription drug. Some sports organizations list it as a prohibited substance because of its potential performance-enhancing properties. Published human data are sparse, so claims about its effects in people often rely on animal models or anecdotal reports. Quality and identity of online materials can vary widely.
Storage conditions for research-grade SR9009 generally involve a freezer at approximately minus twenty degrees Celsius, sometimes lower for long-term preservation. Containers should remain tightly closed and protected from light. Desiccants may be used to limit moisture uptake. Solutions are often stored in aliquots to avoid repeated warming and cooling. Stability data for the compound under various conditions are limited, so laboratories typically follow supplier recommendations and verify performance through periodic analytical checks rather than assuming indefinite stability.
Identity and purity testing for SR9009 commonly uses liquid chromatography coupled with tandem mass spectrometry. This method separates the compound from matrix components and detects it by mass-to-charge transitions, providing sensitive and specific confirmation. Nuclear magnetic resonance spectroscopy can support structural identification, while high-performance liquid chromatography with ultraviolet detection may estimate purity. Because online products labeled as SR9009 may contain other substances or no active compound at all, independent verification is important in research settings. Certificates of analysis are useful but not a substitute for in-house testing.
Laboratory samples of SR9009 are typically supplied as a white to off-white powder. The compound dissolves readily in organic solvents such as dimethyl sulfoxide and ethanol, while its solubility in water is low. Because of this solubility profile, researchers often prepare concentrated stock solutions in an organic solvent before diluting them into aqueous assay buffers. Light exposure, moisture, and repeated freeze-thaw cycles can degrade many small molecules, so handling procedures usually aim to minimize these factors. Purity is commonly checked before use.
| Property | Value | Notes |
|---|---|---|
| Chemical class | Synthetic REV-ERB agonist | Small-molecule ligand; not a hormone or peptide |
| Molecular formula | C20H24ClN3O4S | Reported for the free base |
| CAS Registry Number | 1379686-30-2 | Unique chemical identifier |
| Common synonyms | SR9009; stenabolic | Stenabolic is informal and not an official name |
| Reported targets | REV-ERBα and REV-ERBβ | Nuclear receptors linked to circadian and metabolic regulation |
Laboratory identification of SR9009 typically relies on chromatographic separation coupled to mass spectrometry, often with ultraviolet detection as a secondary check. Nuclear magnetic resonance spectroscopy can confirm molecular structure when a reference standard is available. Because many suppliers sell the compound as a research chemical, independent identity testing is important for experimental reproducibility. A single retention time is not sufficient proof of identity, especially when related compounds may be present. Purity assessments usually report a percentage based on area normalization.
SR9009 is generally described as poorly soluble in water and more soluble in organic solvents such as dimethyl sulfoxide and ethanol. Stock solutions are commonly prepared in an organic solvent before dilution into an aqueous buffer or vehicle. Precipitation can occur if the organic fraction is reduced too quickly or if the final concentration exceeds the compound's solubility limit. Sonication or gentle warming may aid dissolution in some protocols, but excessive heat can promote degradation. Container material and pH can also influence observed solubility.
For long-term storage, SR9009 is typically kept as a solid at low temperature, protected from moisture and light. Desiccated conditions limit hydrolysis, while opaque containers reduce photochemical breakdown. Solutions are less stable than solids and are often stored frozen in aliquots to avoid repeated freeze-thaw cycles. Stability data are not standardized across all suppliers, so users should rely on certificate-of-analysis information when available. Degradation may appear as color change, precipitate, or decreased chromatographic purity.
SR9009 is a synthetic small molecule studied as an agonist of the nuclear receptors REV-ERBα and REV-ERBβ. These receptors help regulate circadian rhythms, lipid metabolism, and inflammatory gene expression. In cell and animal experiments, SR9009 alters transcription of clock-controlled genes and metabolic pathways. The compound is not a hormone and does not resemble classical steroid structures. Its activity depends on binding to the ligand-binding domain of REV-ERB, where it can modify corepressor recruitment.
Research interest in SR9009 grew from studies of circadian biology and metabolic disease. Preclinical reports describe effects on exercise capacity, muscle metabolism, and blood lipid levels in rodents, but these findings come from controlled laboratory settings. The compound has low oral bioavailability in animals, which limits systemic exposure after swallowing. Investigators often use injected routes in experiments to achieve measurable plasma concentrations. Human clinical data are sparse, no approved therapeutic product exists, and whether animal effects translate to humans remains an open question.
Regulatory and sporting contexts treat SR9009 as a prohibited substance in many elite competitions. Its presence on banned lists reflects concerns about performance enhancement and unknown long-term safety. Analytical chemists have developed methods to detect the parent compound and its metabolites in urine and blood. Literature discussions distinguish between in vitro potency, animal pharmacology, and anecdotal human reports. The latter are difficult to verify because products sold online may lack purity or contain different compounds.
It may be formed by directly fluorinating bromine at room temperature and is purified through distillation. It reacts violently with water and explodes on contact with flammable materials, but is a less powerful fluorinating reagent than chlorine trifluoride. It reacts vigorously with boron, carbon, silicon, arsenic, antimony, iodine, and sulfur to give fluorides, and will also convert most metals and many metal compounds to fluorides; as such, it is used to oxidise uranium to uranium hexafluoride in the nuclear power industry. Refractory oxides tend to be only partially fluorinated, but here the derivatives KBrF4 and BrF2SbF6 remain reactive. Bromine trifluoride is a useful nonaqueous ionising solvent, since it readily dissociates to form BrF2+ and BrF4− and thus conducts electricity. Bromine pentafluoride (BrF5) was first synthesised in 1930. It is produced on a large scale by direct reaction of bromine with excess fluorine at temperatures higher than 150 °C, and on a small scale by the fluorination of potassium bromide at 25 °C. It also reacts violently with water and is a very strong fluorinating agent, although chlorine trifluoride is still stronger.
=== Antimicrobials === Aminoglycosides — an antibacterial; its use is extremely restricted due to risk of hearing loss and kidney damage. Amphotericin B — used for life-threatening fungal infections and primary amoebic meningoencephalitis; its side effects are often severe or potentially fatal. Carbapenems (such as imipenem/cilastatin) — used as a drug of last resort for a variety of different bacterial infections; use is limited to prevent development of drug resistance. Ceftobiprole and ceftaroline — fifth-generation cephalosporins active against methicillin-resistant Staphylococcus aureus (MRSA); use is limited to prevent development of drug resistance. Cefiderocol — a cephalosporin used to treat complicated urinary tract infections (cUTI) caused by multi-drug resistant Gram-negative bacteria in patients with limited or no alternative options; use is limited for other MDRGN bacteria since its safety and efficacy have not been established. Chloramphenicol — formerly first-line therapy for Rocky Mountain spotted fever (until doxycycline became available), current first-line therapy (topically) for bacterial conjunctivitis, and (systemically) for meningitis when allergies to penicillin or cephalosporin exist; use of intravenous chloramphenicol carries unacceptably high risk of irreversible, fatal aplastic anemia and gray baby syndrome. Colistin — used against certain life-threatening infections, such as those caused by Pseudomonas; carries risk of kidney and nerve damage.
On July 3, 2023, a complaint was filed stating the Boston Market in Danbury, Connecticut, owed in excess of $61,000 in unpaid rent and connected charges. A ruling in the landlord's favor on July 28, 2023, led to an eviction. On July 25, 2023, US Foods sued Boston Market for $11.3 million, accusing the company of owing them over $10 million for food distributed over several prior years. On August 14, 2023, the New Jersey Department of Labor and Workforce Development issued a stop-work order at 27 of the 31 Boston Market stores in New Jersey over multiple violations of workers rights, including owed backpay of up to $607,471 to up to 314 employees. An investigation on the matter began in November 2022 when an employee in Mercer County filed a complaint. The affected employees have since been reimbursed for their lost wages, and the stores were allowed to re-open a month later. In September 2023, investigative journalists of Restaurant Business Magazine revealed Pandya had over 200 lawsuits against him related to unpaid wages of employees, unpaid suppliers, and other violations related to his restaurants. The report described Pandya's ownership of Boston Market as "chaotic". In November 2023, the company failed to pay workers in Massachusetts. On November 14, 2023, all Detroit-area Boston Market locations were permanently shuttered and were handed eviction notices due to unpaid rent.
== Plot == A homeless Ren and Stimpy are caught again and sent to the dog pound, where they are sent to their imminent death. They are saved by an unnamed rich and senile lady (Granny) on the verge of death while a priest ordains them in a gas chamber. The duo feed themselves in Granny's limousine, grateful of their survival, when the woman decides to name them "Abraham" and "Levictus" which they reluctantly allow. The duo settle at their new home. Ren decides to shake hands with a dog he believes is a fellow pet. At first, Ren assumes the dog is sleeping and attempts to wake him up, only to discover that he is dead; Granny explains that the dog is a previous pet of hers named Ezekiel who died in his sleep, so his corpse was freeze-dried in a successful attempt of taxidermy. Suddenly, the duo are condemned by the lady for being apparently possessed, despite acting normal for their kind, as they are handed off to the lady's butler Mr. Hao, a stereotypical Chinese muscular man who beats them to a pulp. The duo, who cannot walk normally after the beating, are forced to eat literal rocks advertised as dog food. Ren breaks his teeth doing so while Stimpy chokes on it; Ren's unsuccessful attempt of the Heimlich maneuver is seen as a threat by Granny, who sprays Stimpy with water and forces him to spit. She sends them to a veterinarian who further harms them. The duo sleep in the living room when Granny forcibly moves them to the yard; they find that it is a cemetery for her pets.
Sources: en.wikipedia.org
Some effects are dependent upon the route of administration, with intravenous use associated with the transmission of many disease such as hepatitis C, HIV/AIDS, and potential medical emergencies such as infection, thrombosis, or pseudoaneurysm, while inhalation may be associated with increased lower respiratory tract infection, lung cancer, and pathological restricting of lung tissue. Cocaine may also increase risk for autoimmune disease and damage nasal cartilage. Abuse of methamphetamine produces similar effects as well as marked degeneration of dopaminergic neurons, resulting in an increased risk for Parkinson's disease.
== Structure == The mechanism of enzymatic catalysis by the BCKDC draws largely upon the elaborate structure of this large enzyme complex. This enzyme complex is composed of three catalytic components:
=== Box-office === The film opened on 6 November 1987 in limited release in 27 cinemas in eight U.S. markets. During its opening weekend, the film opened in 19th place and grossed $318,723. The film was originally set to expand on 20 November 1987, but it was delayed until February 1988. The film expanded to 479 screens for the weekend of 19–21 February and went on to gross $5,899,797 in the United States and Canada. The film was released in South Africa in July 1988 but was seized by police who claimed it was a threat to national security. It was approved for release the following month in several bantustans in South Africa. Internationally, the film grossed $46 million, for a worldwide total of $52 million. It earned £3,313,150 in the UK.
Sources: en.wikipedia.org
=== Diet === Diet is the most essential factor to work on in people with anorexia nervosa, and must be tailored to each person's needs. Food variety is important when establishing meal plans as well as foods that are higher in energy density, especially in carbohydrates and dietary fat, which are easier for the undernourished body to break down. Evidence of a role for zinc supplementation during refeeding is unclear. Dieticians work with the medical team to add dietary supplements like iron, every other day, or calcium. Historically, practitioners have slowly increased calories at a measured pace from a starting point of around 1,200 kcal/day. However, as understanding of the process of weight restoration has improved, an approach that favors a higher starting point and a more rapid rate of increase has become increasingly common. In either approach, the end goal is typically in the range of 3,000 to 3,500 kcal/day.
==== Eliminated in primary ==== Jaimy Blanco, real estate investor Michael Curran, professor Crystal DeLeon-Sarmiento, Manvel city councilor Dan Mims, San Jacinto College trustee Steve Stockman, former U.S. representative from the 36th district (2013–2015) and this district (1995–1997) and candidate for U.S. Senate in 2014 Terry Thain, railcar terminal operations manager
The fat humps of camels are a source of meat in some cultures. Khlii, a camel meat dish from Algeria, is prepared in a mixture of fat from the camel's hump and kidneys. Camel hump fat is high in saturated fatty acids, with as much as 64.4% of the hump's weight basis consisting of them, and another 33.1% of its weight basis is monounsaturated fats. Bison humps, despite consisting of muscle instead of fat, are also considered a delicacy by some; William Temple Hornaday called sliced and fried bison hump "a dish fit for the gods".In markets where zebu are valued, humps can provide the breeder with higher income. In such markets, cattle may be selectively bred to have a large hump, so as to indicate a pure zebu bloodline. Siddi breeders backcross herds that have mixed too much with humpless cattle, selcting for taller bulls with larger humps, as these will be worth more than humpless bulls. Certain landforms may be named due to their resemblance of animal humps. Camel's Hump in Vermont and Buffalo Hump in Idaho are two such examples. Humans may also take their names from animal humps, such as the Comanche war chief Buffalo Hump. Some HIV-1 patients develop a fat deposit nicknamed a "buffalo hump", though this forms on the patient's neck, as opposed to between the shoulders in an actual bison.
Sources: en.wikipedia.org
SR9009 is a synthetic compound investigated as an agonist of the nuclear receptors REV-ERBα and REV-ERBβ. It is used in preclinical research on circadian rhythm and metabolism. It is not an approved drug.
No. It has no approved medical indication, and human safety and efficacy data are limited. It appears in research chemical markets and is banned by some sports authorities.
Natural ligands include heme and certain metabolites; SR9009 is a synthetic small molecule with higher potency and selectivity in some assays. Its effects depend on cell type and timing. It is not a naturally occurring compound.
Research-grade SR9009 is typically stored frozen at about minus twenty degrees Celsius, protected from light and moisture. Stock solutions are often kept in aliquots to avoid repeated freeze-thaw cycles. Specific storage conditions should follow the supplier's documentation.